Amyloid precursor proteins, neural differentiation in pluripotent stem cells and relevance to Alzheimer's disease

Khandekar, Neeta, Lie, Kuhn, Sachdev, Perminder and Sidhu, Kuldip S. (2012) Amyloid precursor proteins, neural differentiation in pluripotent stem cells and relevance to Alzheimer's disease. Stem Cells and Development, 21 7: 997-1006.

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Author Khandekar, Neeta
Lie, Kuhn
Sachdev, Perminder
Sidhu, Kuldip S.
Title Amyloid precursor proteins, neural differentiation in pluripotent stem cells and relevance to Alzheimer's disease
Journal name Stem Cells and Development   Check publisher's open access policy
ISSN 1547-3287
1557-8534
Publication date 2012-04-20
Sub-type Article (original research)
DOI 10.1089/scd.2011.0564
Volume 21
Issue 7
Start page 997
End page 1006
Total pages 10
Editor Graham C. Parker
Place of publication New Rochelle, NY, USA
Publisher Mary Ann Liebert
Collection year 2013
Language eng
Abstract Alzheimer’s disease is a leading cause of age-related dementia that is characterized by an extensive loss of neurons and synaptic transmission. The pathological hallmarks of AD are: neurofibrillary tangles and deposition of β-amyloid (Aβ) plaques. Previous research has investigated how Aβ fragments disrupt synaptic mechanisms in the vulnerable regions of the brain. There is a tremendous potential for stem cell technology to extend upon this research not only in terms of developing therapeutic applications, but also in modeling AD. Indeed, the advent of induced pluripotent stem cell technology has opened up exciting new avenues for generating patient and disease-specific cell lines from somatic cells that may be used to model AD. Amyloid precursor protein (APP) is a key protein in neuronal development and this article reviews the role of APP in AD. Stem cell technology offers the opportunity to make use of APP in the directed differentiation of induced pluripotent stem cells into functional neurons, a process that may help generate a model of AD and thereby facilitate an understanding of the mechanisms underlying this disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Online Ahead of Print: January 18, 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Chemistry and Molecular Biosciences
 
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Created: Mon, 05 Dec 2011, 10:30:17 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences