Exhaled breath temperature in healthy children is influenced by room temperature and lung volume

Logie, Karla M., Kusel, Merci M.H., Sly, Peter D. and Hall, Graham L. (2011) Exhaled breath temperature in healthy children is influenced by room temperature and lung volume. Pediatric Pulmonology, 46 11: 1062-1068. doi:10.1002/ppul.21488

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Author Logie, Karla M.
Kusel, Merci M.H.
Sly, Peter D.
Hall, Graham L.
Title Exhaled breath temperature in healthy children is influenced by room temperature and lung volume
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 8755-6863
1099-0496
Publication date 2011-11
Sub-type Article (original research)
DOI 10.1002/ppul.21488
Volume 46
Issue 11
Start page 1062
End page 1068
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2012
Language eng
Formatted abstract
Background
Exhaled breath temperature (EBT) has been proposed for the non-invasive assessment of airway inflammation. Previous studies have not examined the influence of room temperature or lung size on the EBT.

Objective
This study aimed to address these issues in healthy children.

Methods
We assessed the effects of room temperature and lung volume in 60 healthy children aged 9-11 years (mean age 10.3 years, 33 male). Static lung volumes were assessed using multiple breath nitrogen washout. Questionnaire and skin prick tests were also used to establish respiratory health in the children. We obtained the EBT parameters of slope, end plateau temperature (PLET) and normalized plateau temperature (nPLET; plateau temperature minus inspired air temperature), and ascertained physiological factors influencing EBT.

Results
End plateau temperature was shown to be proportionally affected by room temperature (r=0.532, P<0.001) whereas slope and nPLET decreased with increasing room temperature (r=-0.392 P<0.02 and r=-0.507 P=0.002). After adjusting for room temperature, height and age, the total lung capacity (r 2=0.435, P=0.006) and slow vital capacity (SVC; r 2=0.44, P=0.005) were found to be the strongest predictors of end PLET in healthy children. When all factors were included in a multiple regression model, SVC and room temperature were the only predictors of plateau and nPLET. Slope was only influenced by room temperature.

Conclusions

Exhaled breath temperature measurements are highly feasible in children with a 95% success rate in this healthy population. Room temperature and SVC significantly influence EBT variables in healthy children. Further studies are required to investigate the ability of EBT to assess airway inflammation in children with respiratory disease.
Keyword Children
Exhaled breath temperature
Lung volume
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 27 May 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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