Pegfilgrastim to support CHOP-14 in elderly patients with non-Hodgkin's lymphoma

Wolf, Max, Bentley, Mark, Marlton, Paula, Horvath, Noemi, Lewis, Ian D., Spencer, Andrew, Herrmann, Richard, Arthur, Chris, Durrant, Simon, Van Kerkhoven, Marilyn, Macmillan, Jamie and Mrongovius, Robert (2006) Pegfilgrastim to support CHOP-14 in elderly patients with non-Hodgkin's lymphoma. Leukemia and Lymphoma, 47 11: 2344-2350. doi:10.1080/10428190600881017


Author Wolf, Max
Bentley, Mark
Marlton, Paula
Horvath, Noemi
Lewis, Ian D.
Spencer, Andrew
Herrmann, Richard
Arthur, Chris
Durrant, Simon
Van Kerkhoven, Marilyn
Macmillan, Jamie
Mrongovius, Robert
Title Pegfilgrastim to support CHOP-14 in elderly patients with non-Hodgkin's lymphoma
Journal name Leukemia and Lymphoma   Check publisher's open access policy
ISSN 1042-8194
1029-2403
Publication date 2006-11
Sub-type Article (original research)
DOI 10.1080/10428190600881017
Volume 47
Issue 11
Start page 2344
End page 2350
Total pages 7
Place of publication London, Engalnd, U.K.
Publisher Informa Healthcare
Language eng
Formatted abstract
This study investigated whether pegfilgrastim support would enable on-schedule delivery of dose-dense cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP-14) to elderly patients with non-Hodgkin's lymphoma (NHL). Thirty patients 60 years of age and older with aggressive NHL were evaluated after receiving up to six cycles of CHOP-14 supported with pegfilgrastim. The median age was 68 years (range 61-74). Forty-seven per cent of patients received full dose chemotherapy on schedule for all cycles (range 65-93). Chemotherapy was delayed in 10 patients and dose reduced in 15 patients. Hematological toxicity was the most common reason for delays and dose reduction. Six of nine patients (67%) achieved a peripheral blood CD34+ count of at least 20 cells 106L-1 on day 12 of cycle one. The delivery on schedule of dose-dense CHOP-14 to elderly patients with previously untreated aggressive NHL is safe and efficacious with once per cycle pegfilgrastim support.
Keyword Chop-14
G-Csf
Elderly
Non-Hodgkin's lymphoma
Pegfilgrastim
Mobilization
Colony-Stimulating Factor
Chemotherapy
Filgrastim
Guidelines
Management
Cancer
Trial
Age
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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