Cognitive functioning in older twins: The older Australian twins study

Sachdev, Perminder S., Lee, Teresa, Lammel, Andrea, Crawford, John, Trollor, Julian N., Wright, Margaret J., Brodaty, Henry, Ames, David, Martin, Nicholas G. and OATS Research Team (2011) Cognitive functioning in older twins: The older Australian twins study. Australasian Journal on Ageing, 30 Supp. 2: 17-23. doi:10.1111/j.1741-6612.2011.00534.x

Author Sachdev, Perminder S.
Lee, Teresa
Lammel, Andrea
Crawford, John
Trollor, Julian N.
Wright, Margaret J.
Brodaty, Henry
Ames, David
Martin, Nicholas G.
OATS Research Team
Title Cognitive functioning in older twins: The older Australian twins study
Journal name Australasian Journal on Ageing   Check publisher's open access policy
ISSN 1440-6381
Publication date 2011-10
Sub-type Article (original research)
DOI 10.1111/j.1741-6612.2011.00534.x
Volume 30
Issue Supp. 2
Start page 17
End page 23
Total pages 7
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2012
Language eng
Formatted abstract
Aim: To examine the concordance rates of common medical conditions and neurocognitive performance in monozygotic (MZ) and dizygotic (DZ) older twins. 

Methods: Twins aged 65 years and living in the three Eastern states of Australia were recruited through the Australian Twin Registry and underwent detailed neuropsychological and medical assessment. 

Results: Assessments were conducted on 113 MZ and 96 DZ twin pairs, with a mean age of 70.5 years. MZ twins were more concordant than DZ twins for hypertension and asthma. MZ twins had higher correlations than DZ twins on most neuropsychological tests, with the exception of some tests related to processing speed. The concordance rate for mild cognitive impairment or dementia was 76.2% in MZ twins and 42.9% in DZ twins, a non-significant difference. 

Conclusions: Except for some aspects of processing speed, most cognitive functions in older individuals show significant heritability. The heritability of neurocognitive disorders is, however, low.   
Keyword Ageing
Cognitive function
Mild cognitive impairment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
School of Psychology Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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