Vitamin D in fetal brain development

Eyles, Darryl, Burne, Thomas and McGrath, John (2011) Vitamin D in fetal brain development. Seminars in Cell and Developmental Biology, 22 6: 629-636. doi:10.1016/j.semcdb.2011.05.004

Author Eyles, Darryl
Burne, Thomas
McGrath, John
Title Vitamin D in fetal brain development
Journal name Seminars in Cell and Developmental Biology   Check publisher's open access policy
ISSN 1084-9521
Publication date 2011-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcdb.2011.05.004
Volume 22
Issue 6
Start page 629
End page 636
Total pages 8
Place of publication Kent, United Kingdom
Publisher Academic Press
Collection year 2012
Language eng
Abstract In this review we will provide a concise summary of the evidence implicating a role for vitamin D in the developing brain. Vitamin D is known to affect a diverse array of cellular functions. Over the past 10 years data has emerged implicating numerous ways in which this vitamin could also affect the developing brain including its effects on cell differentiation, neurotrophic factor expression, cytokine regulation, neurotransmitter synthesis, intracellular calcium signaling, anti-oxidant activity, and the expression of genes/proteins involved in neuronal differentiation, structure and metabolism. Dysfunction in any of these processes could adversely affect development. Although there are many ways to study the effects of vitamin D on the developing CNS in vivo, we will concentrate on one experimental model that has examined the impact of the dietary absence of vitamin D in utero. Finally, we discuss the epidemiological data that suggests that vitamin D deficiency either in utero or in early life may have adverse neuropsychiatric implications.
Keyword Brain
Vitamin D deficiency
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
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