Visuospatial encoding deficits and compensatory strategies in schizophrenia revealed by eye movement analysis during a working memory task

Cocchi, Luca, Bosisio, Francesca, Berchtold, Andre, Orita, Alina, Debbane, Martin, Wood, Stephen J. and Schenk, Francoise (2009) Visuospatial encoding deficits and compensatory strategies in schizophrenia revealed by eye movement analysis during a working memory task. Acta Neuropsychiatrica, 21 2: 75-83. doi:10.1111/j.1601-5215.2009.00369.x


Author Cocchi, Luca
Bosisio, Francesca
Berchtold, Andre
Orita, Alina
Debbane, Martin
Wood, Stephen J.
Schenk, Francoise
Title Visuospatial encoding deficits and compensatory strategies in schizophrenia revealed by eye movement analysis during a working memory task
Journal name Acta Neuropsychiatrica   Check publisher's open access policy
ISSN 0924-2708
1601-5215
Publication date 2009-04
Sub-type Article (original research)
DOI 10.1111/j.1601-5215.2009.00369.x
Volume 21
Issue 2
Start page 75
End page 83
Total pages 9
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Objective: To investigate scanpath abnormalities during the encoding of static stimuli in schizophrenia and their interaction with visuospatial working memory (VSWM) dysfunction.

Methods: Outpatients with schizophrenia and control subjects were asked to encode a static pattern for subsequent recognition after a short delay. We measured the number of correct and incorrect choices. We also assessed the number and the distribution of fixations, the scanning time in specific regions of interest (ROIs) and the head movements during the encoding of the stimuli. The distributions of fixations and scanning time in definite ROIs during the discrimination of the correct pattern from the foils were also measured.

Results:
Patients recognised fewer correct patterns than controls. Correct trials in patients were characterised by a specific exploration of the central part of the stimulus during its presentation, whereas this feature was absent in incorrect trials. However, the scanning time and the numbers of fixations and head movements during encoding were similar in both groups and unrelated to recognition accuracy. In both groups, correct trials were associated with a selective exploration of the correct pattern amongst the six possibilities during recognition. Furthermore, patients gave more attention to incorrect patterns with a leftmost element identical to that of the correct response and also those approximating its global structure.

Conclusion:
Patients showed a VSWM deficit independent of oculomotor dysfunctions and head movements during encoding. Patients’ correct trials were related to specific scanning during encoding and discrimination phases. Analysis of these patterns suggests that patients try to compensate for reduced VSWM ability by using specific encoding strategies.
Keyword Encoding
Eye movement
Fixation
Scanpath
Schizophrenia
Strategy
Visuospatial
Working memory
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
ERA 2012 Admin Only
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 27 Nov 2011, 06:01:04 EST by System User on behalf of Queensland Brain Institute