Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia

Cocchi, Luca, Walterfang, Mark, Testa, Renee, Wood, Stephen J., Seal, Marc L., Suckling, John, Takahashi, Tsutomu, Proffitt, Tina-Marie, Brewer, Warrick J., Adamson, Christopher, Soulsby, Bridget, Velakoulis, Dennis, McGorry, Patrick D. and Pantelis, Christos (2009) Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia. Schizophrenia Research, 115 2-3: 163-172. doi:10.1016/j.schres.2009.09.009


Author Cocchi, Luca
Walterfang, Mark
Testa, Renee
Wood, Stephen J.
Seal, Marc L.
Suckling, John
Takahashi, Tsutomu
Proffitt, Tina-Marie
Brewer, Warrick J.
Adamson, Christopher
Soulsby, Bridget
Velakoulis, Dennis
McGorry, Patrick D.
Pantelis, Christos
Title Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
1573-2509
Publication date 2009-12
Sub-type Article (original research)
DOI 10.1016/j.schres.2009.09.009
Volume 115
Issue 2-3
Start page 163
End page 172
Total pages 10
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Spatial working memory (SWM) dysfunction has been suggested as a trait marker of schizophrenia and implicates a diffuse network involving prefrontal, temporal and parietal cortices. However, structural abnormalities in both grey and white matter in relation to SWM deficits are largely unexplored. The current magnetic resonance imaging (MRI) study examined this relationship in a sample of young first-episode schizophrenia (FES) patients using a whole-brain voxel-based method. SWM ability of 21 FES patients and 41 comparable controls was assessed by the CANTAB SWM task. Using an automated morphometric analysis of brain MRI scans, we assessed the relationship between SWM abilities and both grey matter volume and white matter density in both groups. Our findings demonstrated the different directionality of the association between SWM errors and grey matter volume in left frontal regions and white matter tracts connecting these regions with temporal and occipital areas between FES patients and controls. This suggests that the substrate underpinning the normal variability in SWM function in healthy individuals may be abnormal in FES, and that the normal neurodevelopmental processes that drive the development of SWM networks are disrupted in schizophrenia.
Keyword Voxel-based morphometry
Working memory
Schizophrenia
Grey matter
White matter
First-episode psychosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
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