White matter microstructure in patients with obsessive-compulsive disorder

Bora, Emre, Harrison, Ben J., Fornito, Alex, Cocchi, Luca, Pujol, Jesus, Fontenelle, Leonardo F., Velakoulis, Dennis, Pantelis, Christos and Yucel, Murat (2011) White matter microstructure in patients with obsessive-compulsive disorder. Journal of Psychiatry and Neuroscience, 36 1: 42-46. doi:10.1503/jpn.100082


Author Bora, Emre
Harrison, Ben J.
Fornito, Alex
Cocchi, Luca
Pujol, Jesus
Fontenelle, Leonardo F.
Velakoulis, Dennis
Pantelis, Christos
Yucel, Murat
Title White matter microstructure in patients with obsessive-compulsive disorder
Journal name Journal of Psychiatry and Neuroscience   Check publisher's open access policy
ISSN 1180-4882
1488-2434
Publication date 2011-01
Sub-type Article (original research)
DOI 10.1503/jpn.100082
Open Access Status DOI
Volume 36
Issue 1
Start page 42
End page 46
Total pages 5
Place of publication Ottawa, ON, Canada
Publisher Canadian Medical Association
Collection year 2012
Language eng
Formatted abstract
Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive–compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination.

Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls.

Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity.

Limitations:
The cross-sectional design was the main limitation.

Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.
Keyword Diffusion Tensor
Corpus Callosum
Radial Diffusivity
Voxelwise Analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
 
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