Modelling melanoma in mice

Walker, Graeme J., Soyer, H. P., Terzian, Tamara and Box, Neil F. (2011) Modelling melanoma in mice. Pigment Cell & Melanoma Research, 24 6: 1158-1176. doi:10.1111/j.1755-148X.2011.00923.x

Author Walker, Graeme J.
Soyer, H. P.
Terzian, Tamara
Box, Neil F.
Title Modelling melanoma in mice
Journal name Pigment Cell & Melanoma Research   Check publisher's open access policy
ISSN 1755-1471
Publication date 2011-11-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1755-148X.2011.00923.x
Volume 24
Issue 6
Start page 1158
End page 1176
Total pages 19
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell
Collection year 2012
Language eng
Abstract Phenotypic and molecular heterogeneity in human melanoma has impaired efforts to explain many of the clinically important features of melanoma. For example, many of the underlying mechanisms that might predict age-of-onset, time to metastasis and other key elements in melanoma progression remain unknown. Furthermore, melanoma staging used to predict outcome and treatment has not yet moved beyond a basic phenotypic classification. While molecularly targeted therapies show great promise for melanoma patients, establishing accurate animal models that recapitulate human cutaneous melanoma progression remains a priority. We examine the relevance of mice as models for human melanoma progression and for key molecular and histopathologic variants of melanoma. These mice may be used as preclinical models to probe the relationships between causative mutations, disease progression and outcome for molecularly targeted therapeutics. We ask how new mouse models, or more detailed histopathologic and molecular analyses of existing mouse models, may be used to advance our understanding of genotype-phenotype correlations in this tumour type. This necessarily involves a consideration of the utility of mice as models for ultraviolet radiation-induced melanoma, and how this might be improved.
Keyword Histopathology
Mouse models
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
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Created: Thu, 24 Nov 2011, 11:15:34 EST by Nicole Lin on behalf of Medicine - Princess Alexandra Hospital