Correlation of various published radionuclide glomerular filtration rate estimation techniques and proposed paediatric normative data

Bhatt, Manoj K., Bartlett, Marissa L., Mallitt, Kylie-Ann, McTaggart, Steven and Ravi Kumar, Aravind S. (2011) Correlation of various published radionuclide glomerular filtration rate estimation techniques and proposed paediatric normative data. Nuclear Medicine Communications, 32 11: 1088-1094. doi:10.1097/MNM.0b013e32834b458c

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Author Bhatt, Manoj K.
Bartlett, Marissa L.
Mallitt, Kylie-Ann
McTaggart, Steven
Ravi Kumar, Aravind S.
Title Correlation of various published radionuclide glomerular filtration rate estimation techniques and proposed paediatric normative data
Journal name Nuclear Medicine Communications   Check publisher's open access policy
ISSN 0143-3636
1473-5628
Publication date 2011-11
Sub-type Article (original research)
DOI 10.1097/MNM.0b013e32834b458c
Volume 32
Issue 11
Start page 1088
End page 1094
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2012
Language eng
Formatted abstract
Objective:
The aim of this study is to assess the comparability and interchangeability of the radionuclide glomerular filtration rate (GFR) using different published techniques, and propose normative data for paediatrics.

Methods:
A total of 476 paediatric oncology patients aged 2-17 years, referred between January 2001 and December 2008 for GFR estimation, were reviewed for any potential cause of renal impairment. Sixty-nine patients met the stringent inclusion criteria, and were included in the study. GFR estimation was carried out using either technetium-99m diethylene triamine penta-acetic acid ( 99mTc-DTPA) or chromium-51 EDTA ( 51Cr-EDTA). Multiple GFR results were calculated from the same blood sample data (counts/min/ml), according to previously published GFR estimation techniques using one to three blood samples. These techniques were slope-intercept, slope-only and half life. For slope-intercept techniques, GFR was normalized to body surface area or extracellular fluid volume.

Results:
The GFR values obtained using different techniques were highly variant. The intraclass correlation (ICC) for different methods was moderate (ICC=0.56-0.66). A reliable empiric formula to allow conversion of GFR values from one technique to another could not be derived because of this variability, with some exceptions. 51Cr-EDTA yielded the same or lower variability than 99mTc-DTPA. The British Nuclear Medicine Society-recommended method had the lowest coefficient of variation, with a mean value of 116 (SD 22) normalized to 1.73m 2 for 51Cr-EDTA using two samples.

Conclusion:

The GFR values obtained from different calculation techniques are not readily interchangeable or comparable, with some exceptions. For both 99mTc-DTPA and 51Cr-EDTA, the British Nuclear Medicine Society-recommended technique appears to be the most robust, with the least coefficient of variation.
Keyword Chromium-51 EDTA
Correlation
Glomerular filtration rate
Paediatric
Reference values
Technetium-99m diethylene triamine penta-acetic acid
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received March 15, 2011; Accepted July 25, 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
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