Langerhans cells are precommitted to immune tolerance induction

Shklovskaya, Elena, O'Sullivan, Brendan J., Ng, Lai Guan, Roediger, Ben, Thomas, Ranjeny, Weninger, Wolfgang and de St Groth, Barbara Fazekas (2011) Langerhans cells are precommitted to immune tolerance induction. Proceedings of the National Academy of Sciences of the United States of America, 108 44: 18049-18054. doi:10.1073/pnas.1110076108

Author Shklovskaya, Elena
O'Sullivan, Brendan J.
Ng, Lai Guan
Roediger, Ben
Thomas, Ranjeny
Weninger, Wolfgang
de St Groth, Barbara Fazekas
Title Langerhans cells are precommitted to immune tolerance induction
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
Publication date 2011-11-01
Sub-type Article (original research)
DOI 10.1073/pnas.1110076108
Open Access Status Not Open Access
Volume 108
Issue 44
Start page 18049
End page 18054
Total pages 6
Editor Ralph M. Steinman
Place of publication Washington, United States
Publisher National Academy of Sciences
Collection year 2012
Language eng
Formatted abstract
Antigen-dependent interactions between T lymphocytes and dendritic cells (DCs) can produce two distinct outcomes: tolerance and immunity. It is generally considered that all DC subsets are capable of supporting both tolerogenic and immunogenic responses, depending on their exposure to activating signals. Here, we tested whether epidermal Langerhans cells (LCs) can support immunogenic responses in vivo in the absence of antigen presentation by other DC subsets. CD4 T cells responding to antigen presentation by activated LCs initially proliferated but then failed to differentiate into effector/memory cells or to survive long term. The tolerogenic function of LCs was maintained after exposure to potent adjuvants and occurred despite up-regulation of the costimulatory molecules CD80, CD86, and IL-12, but was consistent with their failure to translocate the NF-κB family member RelB from the cytoplasm to the nucleus. Commitment of LCs to tolerogenic function may explain why commensal microorganisms expressing Toll-like receptor (TLR) ligands but confined to the skin epithelium are tolerated, whereas invading pathogens that breach the epithelial basement membrane and activate dermal DCs stimulate a strong immune response.
Keyword Antigen-specific suppression
CD103(+) dendritic cells
Steady-state conditions
CD4(+) T-cells
Contact hypersensitivity
Transgenic mice
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
UQ Diamantina Institute - Open Access Collection
UQ Diamantina Institute Publications
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