Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium

Park, J. Y., Dahm, C. C., Keogh, R. H., Mitrou, P. N., Cairns, B. J., Greenwood, D. C., Spencer, E. A., Fentiman, I. S., Shipley, M. J., Brunner, E. J., Cade, J. E., Burley, V. J., Mishra, G. D., Kuh, D., Stephen, A. M., White, I. R., Luben, R. N., Mulligan, A. A., Khaw, K. T. and Rodwell, S. A. (2010) Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium. British Journal of Cancer, 103 5: 747-756. doi:10.1038/sj.bjc.6605802

Author Park, J. Y.
Dahm, C. C.
Keogh, R. H.
Mitrou, P. N.
Cairns, B. J.
Greenwood, D. C.
Spencer, E. A.
Fentiman, I. S.
Shipley, M. J.
Brunner, E. J.
Cade, J. E.
Burley, V. J.
Mishra, G. D.
Kuh, D.
Stephen, A. M.
White, I. R.
Luben, R. N.
Mulligan, A. A.
Khaw, K. T.
Rodwell, S. A.
Title Alcohol intake and risk of colorectal cancer: results from the UK Dietary Cohort Consortium
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
Publication date 2010-08-24
Sub-type Article (original research)
DOI 10.1038/sj.bjc.6605802
Open Access Status DOI
Volume 103
Issue 5
Start page 747
End page 756
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Background: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent.
Methods: We investigated the prospective associations between alcohol intake on overall and site- and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ).
Results: Compared with individuals in the lightest category of drinkers (>0–<5 g per day), the multivariable odds ratios of CRC were 1.16 (95% confidence interval (95% CI): 0.88, 1.53) for non-drinkers, 0.91 (95% CI: 0.67, 1.24) for drinkers with 5–<15 g per day, 0.90 (95% CI: 0.65, 1.25) for drinkers with 15–<30 g per day, 1.02 (95% CI: 0.66, 1.58) for drinkers with 30–<45 g per day and 1.19 (95% CI: 0.75, 1.91) for drinkers with ≥45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results.
Conclusion: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.
Keyword Colorectal cancer
Alcohol intake
Prospective cohort study
Food diary
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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