Life Course Models of Socioeconomic Position and Cardiovascular Risk Factors: 1946 Birth Cohort

Murray, Emily T., Mishra, Gita D., Kuh, Diana, Guralnik, Jack, Black, Stephanie and Hardy, Rebecca (2011) Life Course Models of Socioeconomic Position and Cardiovascular Risk Factors: 1946 Birth Cohort. Annals of Epidemiology, 21 8: 589-597. doi:10.1016/j.annepidem.2011.04.005

Author Murray, Emily T.
Mishra, Gita D.
Kuh, Diana
Guralnik, Jack
Black, Stephanie
Hardy, Rebecca
Title Life Course Models of Socioeconomic Position and Cardiovascular Risk Factors: 1946 Birth Cohort
Journal name Annals of Epidemiology   Check publisher's open access policy
ISSN 1047-2797
Publication date 2011-08
Sub-type Article (original research)
DOI 10.1016/j.annepidem.2011.04.005
Volume 21
Issue 8
Start page 589
End page 597
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
PURPOSE: To identify the life course model that best describes the association between life course socioeconomic position (SEP) and cardiovascular (CVD) risk factors (ie, body mass index [BMI], systolic and diastolic blood pressure, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, and glycated hemoglobin) and explore BMI across the life course as mediators of the relationship.
METHODS: The Medical Research Council National Survey of Health and Development was used to compare partial F-tests of simpler nested life course SEP models corresponding to critical period, accumulation, and social mobility models with a saturated model. Then, the chosen life course model for each CVD risk factor was adjusted for BMI at age 53 and lifetime BMI (ages 4, 26, 43, and 53 years).
RESULTS: Among women, SEP was generally associated with CVD risk factors in a cumulative manner, whereas childhood critical period was the prominent model for men. When the best-fitting SEP models were used, we found that adjustment for BMI at age 53 reduced associations for all outcomes in both genders.  Further adjustment for lifetime BMI (4, 26, 43, and 53 years) did not substantially alter most associations
(except for triglycerides).
CONCLUSIONS: SEP at different points across life influences CVD risk factors differently in men and women.
Keyword Accumulation
Cardiovascular Risk
Life Course
Social Class
Social Mobility
United Kingdom
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Available online 5 July 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
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