Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents

Ginty, F., Cavadini, C., Michaud, P. A., Burckhardt, P., Baumgartner, M., Mishra, G. D. and Barclay, D. V. (2004) Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents. European Journal of Clinical Nutrition, 58 9: 1257-1265. doi:10.1038/sj.ejcn.1601959


Author Ginty, F.
Cavadini, C.
Michaud, P. A.
Burckhardt, P.
Baumgartner, M.
Mishra, G. D.
Barclay, D. V.
Title Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents
Journal name European Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0954-3007
1476-5640
Publication date 2004-09
Sub-type Article (original research)
DOI 10.1038/sj.ejcn.1601959
Volume 58
Issue 9
Start page 1257
End page 1265
Total pages 9
Place of publication London, United Kingdom
Publisher Nature
Language eng
Formatted abstract
Objective: To evaluate the effects of nutrient intake and vitamin D status on markers of type I collagen formation and degradation in adolescent boys and girls.

Design: Cross-sectional study.

Setting: Canton of Vaud, West Switzerland. Subjects: A total of 92 boysand 104 girls, aged 11-16y. Data were collected on height, weight, pubertal status (self-assessment of Tanner stage), nutrient intake (3-day dietary record) and fasting serum concentration of 25-hydroxyvitamin D (25OHD), and markers of collagen formation (P1NP) and degradation (serum C-terminal telopeptides: S-CTX).

Results: Tanner stage was a significant determinant of P1NP in boys and girls and S-CTX in girls. Of the nutrients examined, only the ratio of calcium to phosphorus (Ca/P) was positively associated with P1NP in boys, after adjustment for pubertal status. 25OHD decreased significantly at each Tanner stage in boys. Overall, 15% of boys and 17% of girls were identified as being vitamin D insufficient (serum 25OHD < 30 nmol/l), with the highest proportion of insufficiency at Tanner stage 4-5 (29%) in boys and at Tanner stage 3 (24%) in girls. A significant association was not found between 25OHD and either bone turnover marker, nor was 25OHD insufficiency associated with higher concentrations of the bone turnover markers.

Conclusions: The marked effects of puberty on bone metabolism may have obscured any possible effects of diet and vitamin D status on markers of bone metabolism. The mechanistic basis for the positive association between dietary Ca/P ratio and P1NP in boys is not clear and may be attributable to a higher Ca intake per se, a critical balance between Ca and P intake or higher dairy product consumption. A higher incidence of vitamin D insufficiency in older adolescents may reflect a more sedentary lifestyle or increased utilisation of 25OHD, and suggests that further research is needed to define their requirements.
Keyword Adolescence
Dietary intake
25-hydroxyvitamin D
N-propeptide type I collagen
C-telopeptide type I collagen
Bone turnover
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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