Clinical features, diagnosis, and management of the antiphospholipid syndrome

Wong, Richard C. W. and Favaloro, Emmanuel J. (2008) Clinical features, diagnosis, and management of the antiphospholipid syndrome. Seminars in Thrombosis and Hemostasis, 34 3: 295-304. doi:10.1055/s-0028-1082275

Author Wong, Richard C. W.
Favaloro, Emmanuel J.
Title Clinical features, diagnosis, and management of the antiphospholipid syndrome
Journal name Seminars in Thrombosis and Hemostasis   Check publisher's open access policy
ISSN 0094-6176
Publication date 2008-04
Sub-type Article (original research)
DOI 10.1055/s-0028-1082275
Volume 34
Issue 3
Start page 295
End page 304
Total pages 10
Editor Emmanuel J. Favaloro
Richard C. W. Wong
Place of publication New York, United States
Publisher Thieme Medical Publishers
Language eng
Abstract Almost 30 years after it was first described as a discrete clinical entity, the antiphospholipid syndrome (APS) remains a challenge for clinicians in a wide range of specialities. There remain ongoing issues regarding nomenclature, the expanding range of clinical manifestations, and management of certain APS patient subgroups. In addition to the presence of appropriate clinical features, the diagnosis of APS also fundamentally requires the finding of positive antiphospholipid antibody test result(s), and unfortunately much still has to be done to improve the robustness, reproducibility, and standardization of these assays. This article discusses ongoing dilemmas and issues related to clinical aspects of APS including (i) the derivation of the current nomenclature and the implications of recent proposals for its revision; (ii) the problems that the protean clinical manifestations pose for many clinicians, in particular those not intimately familiar with APS; (iii) the potential pitfalls of applying the APS classification criteria as diagnostic criteria (although no doubt tempting for nonspecialist clinicians); (iv) the concept of seronegative APS and the effect that recent proposed changes in antiphospholipid antibody testing strategies may have on this diagnosis; and finally (v) an overview of key developments in the clinical management of APS patients over the past 30 years.
Keyword Anti-β2GPI antibodies
Anticardiolipin antibodies
Antiphospholipid antibodies
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Special issue: Antiphospholipid Antibodies and the Antiphospholipid Syndrome I: Pathogenesis, Clinical Features, Diagnosis, and Management

Document type: Journal Article
Sub-type: Article (original research)
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