Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: Potential interaction with adjuvant chemotherapy

Walker, David G., Laherty, Richard, Tomlinson, Frank H., Chuah, Teong and Schmidt, Chris (2008) Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: Potential interaction with adjuvant chemotherapy. Journal of Clinical Neuroscience, 15 2: 114-121. doi:10.1016/j.jocn.2007.08.007


Author Walker, David G.
Laherty, Richard
Tomlinson, Frank H.
Chuah, Teong
Schmidt, Chris
Title Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: Potential interaction with adjuvant chemotherapy
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
1532-2653
Publication date 2008-02
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.jocn.2007.08.007
Volume 15
Issue 2
Start page 114
End page 121
Total pages 8
Place of publication Kidlington, United Kingdom
Publisher Churchill Livingstone
Language eng
Abstract Dendritic cell vaccination has been applied to the treatment of a variety of cancers, including malignant astrocytoma. We have treated 13 patients with malignant astrocytoma using dendritic cell vaccination and have shown that this treatment is safe and is likely to be effective in combination with standard adjuvant therapy. Future studies should prospectively incorporate dendritic cell vaccination together with chemotherapy. Ideally, dendritic cell vaccination should be tested in a prospective fashion, in a coordinated trial involving multiple centres.
Keyword Astrocytoma
Glioblastoma
Dendritic cell
Vaccination
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 24 December 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Medicine Publications
 
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