Long-term intraocular pressure fluctuation of primary angle closure disease following laser peripheral iridotomy/iridoplasty

Chen, Yan-yun, Sun, Lan-ping, Thomas, Ravi, Liang, Yuan-bo, Fan, Su-jie, Sun, Xia, Li, Si-zhen, Zhang, Shao-dan and Wang, Ning-li (2011) Long-term intraocular pressure fluctuation of primary angle closure disease following laser peripheral iridotomy/iridoplasty. Chinese Medical Journal, 124 19: 3066-3069. doi:10.3760/cma.j.issn.0366-6999.2011.19.021

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Author Chen, Yan-yun
Sun, Lan-ping
Thomas, Ravi
Liang, Yuan-bo
Fan, Su-jie
Sun, Xia
Li, Si-zhen
Zhang, Shao-dan
Wang, Ning-li
Title Long-term intraocular pressure fluctuation of primary angle closure disease following laser peripheral iridotomy/iridoplasty
Journal name Chinese Medical Journal   Check publisher's open access policy
ISSN 0366-6999
Publication date 2011-10-05
Sub-type Article (original research)
DOI 10.3760/cma.j.issn.0366-6999.2011.19.021
Open Access Status DOI
Volume 124
Issue 19
Start page 3066
End page 3069
Total pages 4
Place of publication Beijing, China
Publisher Zhonghua Yixuehui
Collection year 2012
Language eng
Formatted abstract
Background: Many studies indicated that short-term and long-term intraocular pressure (IOP) fluctuations in primary open angle glaucoma patients might lead to glaucomatous progression. However, seldom study has evaluated the long-term
fluctuation of IOP in primary chronic angle closure diseases. The objective of this study was to investigate the long-term IOP fluctuation of primary angle closure diseases and its associations following laser peripheral iridotomy (LPI) with or without laser peripheral iridoplasty.

Methods: A total of 158 patients with primary angle closure suspect (PACS, n=21), primary angle closure (PAC, n=81) and primary angle closure glaucoma (PACG, n=55) had been treated by LPI with or without laser peripheral iridoplasty and followed up for more than 12 months. IOP was measured with Goldman applanation tonometer. Multivariate linear regression with generalized estimating equation (GEE) regression models was used to evaluate the association of long-term IOP fluctuation (maximum IOP minus minimum IOP) with gender, age, baseline IOP, baseline peripheral anterior synechia (PAS), baseline vertical cup/disc ratio (VCDR), baseline mean deviation (MD), need for IOP-lowering medications.

Results: IOP fluctuation during follow-up in PACS, PAC and PACG groups were (4.83±2.90), (5.67±3.35), and (9.40±7.14) mmHg, respectively. IOP fluctuation was strongly correlated with baseline IOP (r=0.356, P <0.001), PAS (r=0.374, P <0.001).
IOP fluctuation was higher in patients with higher baseline IOP (0.18 mmHg per unit increase, 95% CI: 0.05–0.31 mmHg).

Conclusions: Long-term IOP fluctuation in PACG group was larger than that in PACS or PAC group. Eyes with higher
baseline IOP were observed to have larger long-term IOP fluctuation.
Keyword Primary angle closure
Glaucoma
Intraocular pressure
Fluctuation
Peripheral anterior synechia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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