T-cell allorecognition: A case of mistaken identity or déjà vu?

Archbold, Julia K., Macdonald, Whitney A., Burrows, Scott R., Rossjohn, Jamie and McCluskey, James (2008) T-cell allorecognition: A case of mistaken identity or déjà vu?. Trends in Immunology, 29 5: 220-226. doi:10.1016/j.it.2008.02.005

Author Archbold, Julia K.
Macdonald, Whitney A.
Burrows, Scott R.
Rossjohn, Jamie
McCluskey, James
Title T-cell allorecognition: A case of mistaken identity or déjà vu?
Journal name Trends in Immunology   Check publisher's open access policy
ISSN 1471-4906
Publication date 2008-05-01
Sub-type Article (original research)
DOI 10.1016/j.it.2008.02.005
Volume 29
Issue 5
Start page 220
End page 226
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Abstract T cells bearing αβ T-cell receptors (TCRs) are selected by a subset of peptide-laden major histocompatibility (pMHC) molecules in the thymus and in the periphery and therefore are restricted to recognising host or ‘self’ MHC molecules. Nevertheless, T cells are inherently cross-reactive and often react with ‘foreign’ allogeneic MHC molecules (direct T-cell alloreactivity), manifested clinically as organ transplant rejection. Although the basis of T-cell alloreactivity has remained a puzzle to immunologists for decades, studies on alloreactive TCRs have begun to shed light on the basic mechanisms underpinning this ‘mistaken identity’. Here we review recent advances in the field, focusing on structural and cellular studies, showing that alloreactivity may sometimes result from cross-reactivity without molecular mimicry and at other times may result directly from TCR interactions with allogeneic pMHC surfaces that mimic the cognate ligand.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 33 times in Scopus Article | Citations
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Created: Fri, 11 Nov 2011, 11:04:39 EST by Susan Allen on behalf of Institute for Molecular Bioscience