Phage 3396 from a Streptococcus dysgalactiae subsp equisimilis pathovar may have its origins in Streptococcus pyogenes

Davies, Mark R., McMillan, David J., Van Domselaar, Gary H., Jones, Malcolm K. and Sriprakash, Kabada S. (2007) Phage 3396 from a Streptococcus dysgalactiae subsp equisimilis pathovar may have its origins in Streptococcus pyogenes. Journal of Bacteriology, 189 7: 2646-2652. doi:10.1128/JB.01590-06

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Author Davies, Mark R.
McMillan, David J.
Van Domselaar, Gary H.
Jones, Malcolm K.
Sriprakash, Kabada S.
Title Phage 3396 from a Streptococcus dysgalactiae subsp equisimilis pathovar may have its origins in Streptococcus pyogenes
Formatted title
Phage 3396 from a Streptococcus dysgalactiae subsp. equisimilis pathovar may have its origins in Streptococcus pyogenes

Journal name Journal of Bacteriology   Check publisher's open access policy
ISSN 0021-9193
1098-5530
Publication date 2007-04
Sub-type Article (original research)
DOI 10.1128/JB.01590-06
Open Access Status File (Publisher version)
Volume 189
Issue 7
Start page 2646
End page 2652
Total pages 7
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
Streptococcus dysgalactiae subsp. equisimilis strains (group G streptococcus [GGS]) are largely defined as commensal organisms, which are closely related to the well-defined human pathogen, the group A streptococcus (GAS). While lateral gene transfers are emerging as a common theme in these species, little is known about the mechanisms and role of these transfers and their effect on the population structure of streptococci in nature. It is now becoming evident that bacteriophages are major contributors to the genotypic diversity of GAS and, consequently, are pivotal to the GAS strain structure. Furthermore, bacteriophages are strongly associated with altering the pathogenic potential of GAS. In contrast, little is know about phages from GGS and their role in the population dynamics of GGS. In this study we report the first complete genome sequence of a GGS phage, Φ3396. Exhibiting high homology to the GAS phage Φ315.1, the chimeric nature of Φ3396 is unraveled to reveal evidence of extensive ongoing genetic diversity and dissemination of streptococcal phages in nature. Furthermore, we expand on our recent findings to identify inducible Φ3396 homologues in GAS from a region of endemicity for GAS and GGS infection. Together, these findings provide new insights into not only the population structure of GGS but also the overall population structure of the streptococcal genus and the emergence of pathogenic variants.
Keyword Group-A Streptococcus
Complete Genome Sequence
Serotype M3 Strain
Group-C
Nucleotide-Sequence
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
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