Decanalization, brain development and risk of schizophrenia

McGrath, J. J., Hannan, A. J. and Gibson, G. (2011) Decanalization, brain development and risk of schizophrenia. Translational Psychiatry, 1 . doi:10.1038/tp.2011.16


Author McGrath, J. J.
Hannan, A. J.
Gibson, G.
Title Decanalization, brain development and risk of schizophrenia
Journal name Translational Psychiatry   Check publisher's open access policy
ISSN 2158-3188
Publication date 2011-06
Sub-type Article (original research)
DOI 10.1038/tp.2011.16
Open Access Status DOI
Volume 1
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2012
Language eng
Abstract Waddington's original description of canalization refers to the ability of an organism to maintain phenotypic fidelity in the face of environmental and/or genetic perturbation. Development of the human brain requires exposure to a ‘wild-type’ environment—one that supports the optimal set of instructions for development. Recently derived brain structures in our species, such as the expanded neocortex, may be more vulnerable to decanalization because there has been insufficient time to evolve buffering capacity. On the basis of modern notions of decanalization, we provide perspectives on selected environmental and genetic risk factors for schizophrenia, and we discuss strengths and weaknesses of this conceptual framework. We argue that if we are to build a solid foundation for translational psychiatry, we must explore models that attempt to capture the complexity of the interaction between genetic and non-genetic risk factors in mediating and modulating brain development.
Keyword Environmental risk factors
Neurodevelopment
Schizophrenia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # e14

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
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Created: Thu, 10 Nov 2011, 15:39:34 EST by Debra McMurtrie on behalf of Queensland Brain Institute