Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins

Reiersen, Angela M., Constantino, John N., Grimmer, Marisa, Martin, Nicholas G. and Todd, Richard D. (2008) Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins. Twin Research and Human Genetics, 11 6: 579-585. doi:10.1375/twin.11.6.579


Author Reiersen, Angela M.
Constantino, John N.
Grimmer, Marisa
Martin, Nicholas G.
Todd, Richard D.
Title Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
1839-2628
Publication date 2008-12
Sub-type Article (original research)
DOI 10.1375/twin.11.6.579
Volume 11
Issue 6
Start page 579
End page 585
Total pages 7
Place of publication Bowen Hills, Qld., Australia
Publisher Australian Academic Press
Language eng
Formatted abstract
Recent clinic-based and population-based studies have shown evidence of association between ADHD and autistic symptoms in children and adolescents as well as evidence for genetic overlap between these disorders. The objective of the current study was to confirm the association between autistic and ADHD symptoms in a young adult twin sample assessed by self-report, and investigate whether shared genetic and/or environmental factors can explain the association. We performed twin-based structural equation modeling using self-report data from 11 Social Responsiveness Scale (SRS) items and 12 DSM-IV ADHD inattentive and impulsive symptom items obtained from 674 young adult Australian twins. Phenotypic correlation between autistic and ADHD symptoms was moderate. The most parsimonious univariate models for SRS and ADHD included additive genetic effects and unique environmental effects, without sex differences. ADHD and autistic traits were both moderately heritable. In a bivariate model, genetic correlation (rg) between SRS and ADHD was 0.72. Our results suggest that in young adults, a substantial proportion of the genetic influences on self-reported autistic and ADHD symptoms may be shared between the two disorders.
Keyword ADHD
Autism
Comorbidity
Heritability
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
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