Correlates of regular cigarette smoking in a population-based sample of Australian twins

Agrawal, Arpana, Madden, Pamela A. F., Heath, Andrew C., Lynskey, Michael T., Bucholz, Kathleen K. and Martin, Nicholas G. (2005) Correlates of regular cigarette smoking in a population-based sample of Australian twins. Addiction, 100 11: 1709-1719. doi:10.1111/j.1360-0443.2005.01217.x


Author Agrawal, Arpana
Madden, Pamela A. F.
Heath, Andrew C.
Lynskey, Michael T.
Bucholz, Kathleen K.
Martin, Nicholas G.
Title Correlates of regular cigarette smoking in a population-based sample of Australian twins
Journal name Addiction   Check publisher's open access policy
ISSN 0965-2140
1360-0443
Publication date 2005-11
Sub-type Article (original research)
DOI 10.1111/j.1360-0443.2005.01217.x
Volume 100
Issue 11
Start page 1709
End page 1719
Total pages 11
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Aims To investigate the role of measured risk factors and the influence of genetic and environmental factors on regular cigarette smoking.
Design Members of monozygotic and dizygotic, including unlike-sex twin pairs (n = 6257) from a young adult cohort from the Australian Twin Registry.
Methods Cox proportional hazards models were used to determine whether putative risk factors were significantly associated with regular cigarette smoking. Risk factors were classified into four tiers: tier 1 (parental history, including parental education, alcoholism and cigarette smoking), tier 2 (early home and family influences), tier 3 (early life events, e.g. trauma) and tier 4 (psychiatric symptoms/disorders with onset prior to 14 years), after controlling for gender, zygosity and their interactions. Genetic models were fitted to examine the heritability of smoking behavior before and after controlling for significant covariates from the four tiers.
Findings Parental history of cigarette smoking and alcoholism, parental closeness and home environment, as well as incidence of childhood sexual abuse or other trauma, a history of early onset panic attacks and conduct problems were associated with regular cigarette smoking. Important age interactions were found, particularly for family background risk factors. Regular cigarette smoking was moderately heritable, even after accounting for significant covariates.
Conclusions Several measured risk factors are associated with regular smoking. While some of the genetic influences on regular smoking may be shared with these risk factors, a significant proportion of the genetic vulnerability to regular smoking is phenotype-specific.
Keyword Cigarette smoking
Early onset
Risk factors
Survival model
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Wed, 09 Nov 2011, 13:20:32 EST by Miss Kristy Reid on behalf of School of Medicine