An analysis of risk factors for cutaneous melanoma by anatomical site (Australia)

Siskind, Victor, Whiteman, David C., Aitken, Joanne F., Martin, Nicholas G. and Green, Adele C. (2005) An analysis of risk factors for cutaneous melanoma by anatomical site (Australia). Cancer Causes and Control, 16 3: 193-199. doi:10.1007/s10552-004-4325-5


Author Siskind, Victor
Whiteman, David C.
Aitken, Joanne F.
Martin, Nicholas G.
Green, Adele C.
Title An analysis of risk factors for cutaneous melanoma by anatomical site (Australia)
Journal name Cancer Causes and Control   Check publisher's open access policy
ISSN 0957-5243
1573-7225
Publication date 2005-04
Sub-type Article (original research)
DOI 10.1007/s10552-004-4325-5
Volume 16
Issue 3
Start page 193
End page 199
Total pages 7
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Formatted abstract
Objective: Emerging evidence suggests that melanomas arising on the head and neck that are not lentigo maligna melanomas have different associations with phenotypic and environmental risk factors than those on the trunk and other sites. We sought to test this hypothesis in a population-based study in Queensland, Australia.
Methods: Risk factor data were collected from 2360 participants with incident cutaneous melanoma diagnosed 1982–1990, including 167 participants with lentigo maligna melanoma. For each risk factor, polytomous logistic regression analysis, using the trunk as a reference category, was used to estimate the odds ratio and 95% confidence interval for cutaneous melanomas by anatomical site.
Results: Participants with melanomas of the head and neck were significantly older than those with melanomas of the trunk (males 52.7 versus 49.7 years; females 47.8 versus 40.5 years). Compared with patients with truncal melanomas, those of the head and neck were less likely to have many nevi (OR 0.41, 95% CI 0.13–1.31), although this did not reach statistical significance. Among females, melanomas of the lower limb were negatively associated with a past history of non-melanoma skin cancer (OR 0.41, 95% CI 0.23–0.74).
Conclusions: We have observed heterogeneity for melanoma risk by anatomical site, lending weight to the hypothesis that cutaneous melanomas may develop through multiple causal pathways.
Keyword Melanoma
Nevus
Risk factors
Sunburn
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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