Analysis of chromosome 1 microsatellite markers and the FHM2-ATP1A2 gene mutations in migraine pedigrees

Curtain, R. P., Lea, R. A., Tajouri, L., Haupt, L. M., Ovcaric, M., MacMillan, J. and Griffiths, L. R. (2005) Analysis of chromosome 1 microsatellite markers and the FHM2-ATP1A2 gene mutations in migraine pedigrees. Neurological Research, 27 6: 647-652. doi:10.1179/016164105X39978


Author Curtain, R. P.
Lea, R. A.
Tajouri, L.
Haupt, L. M.
Ovcaric, M.
MacMillan, J.
Griffiths, L. R.
Title Analysis of chromosome 1 microsatellite markers and the FHM2-ATP1A2 gene mutations in migraine pedigrees
Formatted title
Analysis of chromosome 1 microsatellite markers and the FHM2-ATP1A2 gene mutations in migraine pedigrees
Journal name Neurological Research   Check publisher's open access policy
ISSN 0161-6412
1743-1328
Publication date 2005-09
Sub-type Article (original research)
DOI 10.1179/016164105X39978
Volume 27
Issue 6
Start page 647
End page 652
Total pages 6
Place of publication Leeds, W. Yorks., United Kingdom
Publisher Maney Publishing
Language eng
Formatted abstract
Objectives: The aims of the study were: (i) to extend our linkage analysis of chromosome 1q microsatellite markers in predominately migraine with aura pedigrees and (ii) to test the novel FHM-2 ATP1A2 gene for involvement in these migraine affected pedigrees and a previous pedigree (MF14) showing evidence of linkage of markers to C1q31.
Methods: A chromosome 1 scan (31 markers) was performed in 21 multiplex pedigrees affected predominately with migraine with aura (MA). The known FHM-2 ATP1A2 gene mutations were tested, by sequencing, for the involvement in MA and migraine without aura (MO) in these pedigrees. Sequencing was performed in the coding areas of the ATP1A2 gene through three MA individuals from MF14.
Results: Evidence for linkage was obtained at C1q23 to markers spanning the ATP1A2 gene. However, testing of the known ATP1A2 gene mutations (for FHM) in common migraine probands of pedigrees showing excess allele sharing was negative. Sequencing of the entire coding areas of the gene through all the three MA affected from MF14 was also negative for mutations.
Discussion: Microsatellite markers on chromosome 1q23 show evidence of excess allele sharing in MA and some MO pedigrees, suggesting linkage to the common forms of migraine and the presence of a susceptibility gene in this region. The FHM-2 (ATP1A2 gene) does not seem to be involved in the common types of migraine. Despite certain clinical characteristics, the genetic correlation between FHM and familial typical migraine remains unclear. Several candidate genes lie within the C1q23 and C1q31 cytogenetic regions; therefore, further studies are needed.
Keyword ATP1A2 gene
Chromosome 1
FHM
MA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Wed, 09 Nov 2011, 12:50:01 EST by Miss Kristy Reid on behalf of School of Medicine