Role of the serrated pathway in colorectal cancer pathogenesis

Leggett, Barbara and Whitehall, Vicki (2010) Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology, 138 6: 2088-2100. doi:10.1053/j.gastro.2009.12.066

Author Leggett, Barbara
Whitehall, Vicki
Title Role of the serrated pathway in colorectal cancer pathogenesis
Journal name Gastroenterology   Check publisher's open access policy
ISSN 0016-5085
Publication date 2010-05
Sub-type Article (original research)
DOI 10.1053/j.gastro.2009.12.066
Volume 138
Issue 6
Start page 2088
End page 2100
Total pages 13
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Language eng
Abstract The "serrated neoplastic pathway" describes the progression of serrated polyps, including sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The recognition of this pathway during the last 15 years has led to a paradigm shift in our understanding of the molecular basis of colorectal cancer and significant changes in clinical practice. These findings are particularly relevant to prevention of interval cancers through colonoscopy surveillance programs-an important issue for colonoscopists. In the past, all serrated polyps were classified simply as hyperplastic polyps and were considered to have no malignant potential. Reappraisal of this view was largely driven by increasing recognition of the malignant potential of hyperplastic polyposis.
Keyword Colorectal cancer
Hyperplastic polyposis
Serrated polyp
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Special issue - Colon Cancer: An Update and Future Directions

Document type: Journal Article
Sub-type: Article (original research)
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Created: Wed, 09 Nov 2011, 11:56:23 EST by Miss Kristy Reid on behalf of School of Medicine