Reddy, Pavan, Negrin, Robert and Hill, Geoffrey R. (2008) Mouse models of bone marrow transplantation. Biology of Blood and Marrow Transplantation, 141, Supplement: 129-135. doi:10.1016/j.bbmt.2007.10.021
Over the last 50 years, mouse models of bone marrow transplantation have provided the critical links between graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) pathophysiology and clinical practice. The initial insight from mouse models that GVHD and GVL were T cell dependent has long been confirmed clinically. More recent translations from mouse models have included the important role of inflammatory cytokines in GVHD. Newly developed concepts relating to the ability of antigen presenting cell (APC) and T cell subsets to mediate GVHD now promise significant clinical advances. The ability to use knockout and transgenic approaches to dissect mechanisms of GVHD and GVL mean that mouse systems will continue as the predominant preclinical platform. The basic transplant approach in these models, coupled with modern “real-time” immunologic imaging of GVHD and GVL is discussed.
Special issue: Hematopoietic Stem Cell Transplantation 2008 Education Supplement Reviews of recent advances in hematopoietic stem cell therapy prepared by clinicians and investigators presenting plenary and simultaneous session papers at the 2008 Tandem BMT Meetings. Published under Section XV: Mouse Models. Available online 24 December 2007