Innate immunity defines the capacity of antiviral T cells to limit persistent infection

Andrews, Daniel M., Estcourt, Marie J., Andoniou, Christopher E, Wikstrom, Matthew E., Khong, Andrea, Voigt, Valentina, Fleming, Peter, Tabarias, Hyacinth, Hill, Geoffrey R., van der Most, Robbert G., Scalzo, Anthony A., Smyth, Mark J. and Degli-Esposti, Mariapia A. (2010) Innate immunity defines the capacity of antiviral T cells to limit persistent infection. Journal of Experimental Medicine, 207 6: 1333-1343. doi:10.1084/jem.20091193

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Author Andrews, Daniel M.
Estcourt, Marie J.
Andoniou, Christopher E
Wikstrom, Matthew E.
Khong, Andrea
Voigt, Valentina
Fleming, Peter
Tabarias, Hyacinth
Hill, Geoffrey R.
van der Most, Robbert G.
Scalzo, Anthony A.
Smyth, Mark J.
Degli-Esposti, Mariapia A.
Title Innate immunity defines the capacity of antiviral T cells to limit persistent infection
Journal name Journal of Experimental Medicine   Check publisher's open access policy
ISSN 0022-1007
Publication date 2010-06-07
Sub-type Article (original research)
DOI 10.1084/jem.20091193
Open Access Status File (Publisher version)
Volume 207
Issue 6
Start page 1333
End page 1343
Total pages 11
Place of publication New York, United States
Publisher Rockefeller University Press
Language eng
Formatted abstract
Effective immunity requires the coordinated activation of innate and adaptive immune responses. Natural killer (NK) cells are central innate immune effectors, but can also affect the generation of acquired immune responses to viruses and malignancies. How NK cells influence the efficacy of adaptive immunity, however, is poorly understood. Here, we show that NK cells negatively regulate the duration and effectiveness of virus-specific CD4+ and CD8+ T cell responses by limiting exposure of T cells to infected antigen-presenting cells. This impacts the quality of T cell responses and the ability to limit viral persistence. Our studies provide unexpected insights into novel interplays between innate and adaptive immune effectors, and define the critical requirements for efficient control of viral persistence.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 114 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 09 Nov 2011, 11:21:17 EST by Miss Kristy Reid on behalf of School of Medicine