Cutaneous melanoma susceptibility and progression genes

de Snoo, Femke A. and Hayward, Nicholas K. (2005) Cutaneous melanoma susceptibility and progression genes. Cancer Letters, 230 2: 153-186. doi:10.1016/j.canlet.2004.12.033

Author de Snoo, Femke A.
Hayward, Nicholas K.
Title Cutaneous melanoma susceptibility and progression genes
Journal name Cancer Letters   Check publisher's open access policy
ISSN 0304-3835
Publication date 2005-12-18
Sub-type Article (original research)
DOI 10.1016/j.canlet.2004.12.033
Volume 230
Issue 2
Start page 153
End page 186
Total pages 34
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Language eng
Abstract This review aims to provide an up-to-date view on our understanding of the molecular genetics of melanoma development. It gives an overview of genes (and loci) currently known to be substantially involved in melanoma predisposition and progression. Broadly, the review falls into 3 sections: genes/loci involved in melanoma susceptibility through germline mutation, tumor suppressor genes somatically mutated or deleted in melanoma, and oncogenes mutated somatically in melanoma. The main cellular pathways in which these genes are involved are summarized and discussed. From this it is evident that abberations of cell cycle regulation, DNA repair and receptor-mediated signal transduction are important for melanocytic neoplasia.
Keyword Melanoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published under Mini-reviews

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Medicine Publications
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Created: Wed, 09 Nov 2011, 11:03:38 EST by Miss Kristy Reid on behalf of School of Medicine