Immunodeficiency-associated lymphomas

Tran, Huy, Nourse, Jamie, Hall, Sara, Green, Michael, Griffiths, Lyn and Gandhi, Maher K. (2008) Immunodeficiency-associated lymphomas. Blood Reviews, 22 5: 261-281. doi:10.1016/j.blre.2008.03.009


Author Tran, Huy
Nourse, Jamie
Hall, Sara
Green, Michael
Griffiths, Lyn
Gandhi, Maher K.
Title Immunodeficiency-associated lymphomas
Journal name Blood Reviews   Check publisher's open access policy
ISSN 0268-960X
1532-1681
Publication date 2008-09-01
Sub-type Article (original research)
DOI 10.1016/j.blre.2008.03.009
Volume 22
Issue 5
Start page 261
End page 281
Total pages 21
Place of publication Kidlington, United Kingdom
Publisher Churchill Livingstone
Language eng
Abstract This article covers lymphoproliferative disorders in patients with primary or acquired immunodeficiencies. Primary immunodeficiences include Ataxia Telangiectasia and X-linked disorders such as Wiskott-Aldrich syndrome. Acquired immunodeficiencies predominantly occur in the setting of infection with the Human Immunodeficiency Virus or arise following immunosuppressive therapy administered after organ transplantation. The rising incidence of HIV throughout the world and the dramatic increase in transplant surgery since the 1990’s suggest that these lymphomas will remain an important health problem. Evidence for lymphoma developing as a result of treatment with methotrexate or Tumour Necrosis Factor Antagonists for autoimmune entities will also be reviewed. The lymphoproliferations that occur with immunodeficiency are extremely heterogenous. In part this reflects the diversity of the causal immune defect. The most striking clinical characteristic is the high frequency of extranodal disease. Frequently, these lymphomas are driven by viruses such as Epstein-Barr virus (EBV), although the lack of EBV in a proportion indicates that alternate pathways must also be involved in the pathogenesis. Lastly, discussion will centre on mechanisms utilized by lymphomas in the immunodeficient as these may have applications to lymphomas in the “immunocompetent”, by serving as a paradigm for the altered immunoregulatory environment present in many lymphoma sub-types.
Keyword Immunodeficiency
Lymphoma
Ataxia Telangiectasia
Combined variable immunodeficiency disorder
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Wed, 09 Nov 2011, 20:58:35 EST by Miss Kristy Reid on behalf of School of Medicine