Technology Insight: Applications of emerging immunotherapeutic strategies for Epstein-Barr virus-associated malignancies

Khanna, Rajiv, Moss, Denis and Gandhi, Maher (2005) Technology Insight: Applications of emerging immunotherapeutic strategies for Epstein-Barr virus-associated malignancies. Nature Clinical Practice Oncology, 2 3: 138-149. doi:10.1038/ncponc0107


Author Khanna, Rajiv
Moss, Denis
Gandhi, Maher
Title Technology Insight: Applications of emerging immunotherapeutic strategies for Epstein-Barr virus-associated malignancies
Journal name Nature Clinical Practice Oncology   Check publisher's open access policy
ISSN 1743-4254
Publication date 2005-03
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/ncponc0107
Volume 2
Issue 3
Start page 138
End page 149
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract The Epstein–Barr virus (EBV) is uniquely associated with a broad range of human malignancies. In spite of their diverse cellular origin, most of these malignancies share common features, including the expression of either some or all of the EBV latent proteins, which can be potentially exploited for immune-based therapies. Here we discuss new and emerging strategies to manipulate the immune response to specifically boost T-cell immunity towards viral proteins that are expressed in EBV-associated malignancies. These strategies are used either alone or as an adjuvant therapy in combination with chemotherapy and/or monoclonal antibodies. Overall, this strategy may serve as a new paradigm for the successful multi-modality treatment of malignancies.
Keyword Cancer
Epstein-Barr virus
Immunotherapy
T cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Current journal title Nature Reviews Clinical Oncology, ISSN: 1759-4774; 1759-4782

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: ERA 2012 Admin Only
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