Interactions between malaria parasites and the host immune system

Engwerda, Christian R. and Good, Michael F. (2005) Interactions between malaria parasites and the host immune system. Current Opinion in Immunology, 17 4: 381-387. doi:10.1016/j.coi.2005.05.010


Author Engwerda, Christian R.
Good, Michael F.
Title Interactions between malaria parasites and the host immune system
Journal name Current Opinion in Immunology   Check publisher's open access policy
ISSN 0952-7915
1879-0372
Publication date 2005-08
Sub-type Article (original research)
DOI 10.1016/j.coi.2005.05.010
Volume 17
Issue 4
Start page 381
End page 387
Total pages 7
Editor Bali Pulendran
Robert A. Seder
Daniel Speiser
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Malaria remains one of the greatest impediments to development in many tropical regions of the world. Understanding host immune responses to malaria parasites is crucial for the effective design and implementation of new vaccines and drugs. Recent research has seen the identification of the first pattern recognition receptor (TLR9) on dendritic cells for a defined product of malaria infection (hemozoin). In addition, progress has been made in understanding the role of dendritic cell subsets in malaria, and how they promote specific components of the host immune response. Potentially important advances in vaccine design have also been made by inserting a Plasmodium sporozoite epitope into the yellow fever vaccine 17D, as well as using a whole, live-attenuated sporozoite vaccine.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Special issue: Host–pathogen interactions / Immunological techniques

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 09 Nov 2011, 10:41:10 EST by Miss Kristy Reid on behalf of School of Medicine