Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: Revisiting old hypotheses

Fleming, Jean S., Beaugie, Clare R., Haviv, Izhak, Chenevix-Trench, Georgia and Tan, Olivia L. (2006) Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: Revisiting old hypotheses. Molecular and Cellular Endocrinology, 247 1-2: 4-21. doi:10.1016/j.mce.2005.09.014


Author Fleming, Jean S.
Beaugie, Clare R.
Haviv, Izhak
Chenevix-Trench, Georgia
Tan, Olivia L.
Title Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: Revisiting old hypotheses
Journal name Molecular and Cellular Endocrinology   Check publisher's open access policy
ISSN 0303-7207
1872-8057
Publication date 2006-03-09
Year available 2005
Sub-type Article (original research)
DOI 10.1016/j.mce.2005.09.014
Volume 247
Issue 1-2
Start page 4
End page 21
Total pages 18
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Language eng
Abstract Epithelial ovarian cancer (EOC) is often a lethal disease because in many cases early symptoms go undetected. Although research proceeds apace, as yet there are few reliable and specific biomarkers for the early stages of the disease. EOC is an umbrella label for a highly heterogeneous collection of cancers, which includes tumours of low malignant potential, serous cystadenomas, mucinous and clear cell carcinomas, all of which are likely to arise from a number of epithelial cell types and a variety of progenitor lesions. Many, but not all types of EOC are thought to arise from the cells lining ovarian inclusion cysts. In this review, we discuss the hypotheses that have driven our ideas on epithelial ovarian carcinogenesis and examine the morphological and genetic evidence for pathways to EOC. The emergence of laser-capture microdissection and expression profiling by microarray technologies offers the promise of defining these pathways more accurately, as well as providing us with the tools for earlier diagnosis.
Keyword Ovulation
Epithelial ovarian cancer
Inflammation
Ovarian inclusion cyst
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 16 November 2005

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
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