Experimental models of cerebral malaria

Engwerda, C., Belnoue, E., Gruner, A. C. and Renia, L. (2005) Experimental models of cerebral malaria. Current Topics in Microbiology and Immunology, 297 103-143. doi:10.1007/3-540-29967-X_4


Author Engwerda, C.
Belnoue, E.
Gruner, A. C.
Renia, L.
Title Experimental models of cerebral malaria
Journal name Current Topics in Microbiology and Immunology   Check publisher's open access policy
ISSN 0070-217X
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1007/3-540-29967-X_4
Volume 297
Start page 103
End page 143
Total pages 41
Place of publication New York, United States
Publisher Springer New York LLC
Language eng
Formatted abstract
Malaria remains a major global health problem and cerebral malaria is one of themost serious complications of this disease. Recent years have seen important advances in our understanding of the pathogenesis of cerebralmalaria. Extensive analysis of tissues and blood taken frompatients with cerebralmalaria has been complimented by the use of animal models to identify specific components of pathogenic pathways. In particular, an important role for CD8+ T cells has been uncovered, as well divergent roles for members of the tumor necrosis factor (TNF) family of molecules, including TNF and lymphotoxin alpha. It has become apparent that theremay bemore than one pathogenic pathway leading to cerebral malaria. The last few years have also seen the testing of vaccines designed to target malaria molecules that stimulate inflammatory responses and thereby prevent the development of cerebral malaria. In this review, we will discuss the above advancements, as well as other important findings in research into the pathogenesis of cerebral malaria. As our understanding of pathogenic responses to Plasmodium parasites gathers momentum, the chance of a breakthrough in the development of treatments and vaccines to prevent death fromcerebralmalaria have become more realistic.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
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Created: Tue, 08 Nov 2011, 22:12:09 EST by Matthew Lamb on behalf of School of Medicine