Renal function in off pump coronary artery bypass (Opcab) surgeries: Effects Of pentastarch and tetrastarch: A double blind randomised trial

Ramanathan, K. R., Banakal, Sanjay and Muralidar, K. (2008) Renal function in off pump coronary artery bypass (Opcab) surgeries: Effects Of pentastarch and tetrastarch: A double blind randomised trial. The Internet Journal of Anesthesiology, 17 2: .

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Author Ramanathan, K. R.
Banakal, Sanjay
Muralidar, K.
Title Renal function in off pump coronary artery bypass (Opcab) surgeries: Effects Of pentastarch and tetrastarch: A double blind randomised trial
Journal name The Internet Journal of Anesthesiology
ISSN 1092-406X
Publication date 2008
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 17
Issue 2
Total pages 10
Place of publication Sugar Land, TX, United States
Publisher Internet Scientific Publications
Language eng
Formatted abstract
Study Objective: To assess and compare the effect of pentastarch(HES 200/0.5) and tetrastarch(HES 130/0.4) on renal function during and after OPCAB surgeries.

Design: Randomized double blind prospective study

Setting: Operating theatre and intensive care unit[ICU] of an academic medical center

Interventions: 30 patients undergoing OPCAB surgery were randomly divided into two groups and were assigned to receive 500 ml of HES(200/0.5) –group H, or HES(130/0.4)-group V immediately after the induction of anesthesia.

Measurements And Results: Markers of glomerular as well as tubular functions were evaluated with blood and urine samples. Tetrastarch did not offer any advantage over pentastarch in patients with normal renal function after OPCAB. However the impact of each starch on postoperative renal functions was different. Tetrastarch did not significantly alter glomerular or tubular function while certain tubular markers like serum and urine sodium were elevated in the postoperative period after administration of pentastarch. However more specific markers like the fractional excretion of sodium and the renal failure index were not significantly changed in the postoperative period.
Keyword Coronary artery bypass grafting
Off pump
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
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Created: Tue, 08 Nov 2011, 10:38:00 EST by Lisa Hennell on behalf of School of Medicine