Determining a synthetic approach to pierisformaside C

Chow, Sharon, Kress, Christoph, Albaek, Nanna, Jessen, Carsten and Williams, Craig M. (2011) Determining a synthetic approach to pierisformaside C. Organic Letters, 13 19: 5286-5289. doi:10.1021/ol202147r

Author Chow, Sharon
Kress, Christoph
Albaek, Nanna
Jessen, Carsten
Williams, Craig M.
Title Determining a synthetic approach to pierisformaside C
Journal name Organic Letters   Check publisher's open access policy
ISSN 1523-7060
Publication date 2011-10
Sub-type Article (original research)
DOI 10.1021/ol202147r
Volume 13
Issue 19
Start page 5286
End page 5289
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2012
Language eng
Formatted abstract
Pieris formosa D. Don (Ericaceae) is a well-known poisonous evergreen shrub found in southwest China.It has been reported that poultry fall into a coma after accidental consumption of the leaves, and even the traditional Chinese name “Mei-Li-Ma-Zui-Mu” described horse enebria after consumption.1 The juice of the fresh leaves has been used in folk medicine as an insecticide or as a lotion for the treatment of tinea and scabies.To date, most grayanane-type diterpenes have been isolated from this species. However, in 2000, Qin isolated pierisformaside C (1),2 which remains the only example possessing three double bonds in a grayanane skeleton. It was to this latter feature that we were most attracted. We reasoned that if a route to 1 could be forged, access to closely related family members (2,33,44,552,6),some of which display prominent biological activity,6,8 might be possible via judicious implementation of hydration reactions (Figure 1).
Keyword Pieris Formosa
Grayanane Diterpenoids
Leucothoe Grayana
Silver(i) Acetylides
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 06 Nov 2011, 01:28:53 EST by System User on behalf of School of Chemistry & Molecular Biosciences