A Possible protective effect of nut consumption on risk of coronary heart-disease: the adventist health study

Fraser, Gary E., Sabate, Joan, Beeson, W. Lawrence and Strahan, T. Martin (1992) A Possible protective effect of nut consumption on risk of coronary heart-disease: the adventist health study. JAMA Internal Medicine, 152 7: 1416-1424. doi:10.1001/archinte.1992.00400190054010

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Author Fraser, Gary E.
Sabate, Joan
Beeson, W. Lawrence
Strahan, T. Martin
Title A Possible protective effect of nut consumption on risk of coronary heart-disease: the adventist health study
Journal name JAMA Internal Medicine   Check publisher's open access policy
ISSN 2168-6106
Publication date 1992-07-01
Sub-type Article (original research)
DOI 10.1001/archinte.1992.00400190054010
Open Access Status File (Publisher version)
Volume 152
Issue 7
Start page 1416
End page 1424
Total pages 9
Place of publication Chicago, IL, United States
Publisher American Medical Association
Language eng
Formatted abstract
Background:  Although dietary factors are suspected to be important determinants of coronary heart disease (CHD) risk, the direct evidence is relative-lse.

Methods:  The Adventist Health Study is a prospective cohort investigation of 31 208 non-Hispanic white California Seventh-Day Adventists. Extensive dietary information was obtained at baseline, along with the values of traditional coronary risk factors. These were related to risk of definite fatal CHD or definite nonfatal- dial infarction.

Results:  Subjects who consumed nuts frequently (more than four times per week) experienced substantially fewer definite fatal CHD events (relative risk, 0.52; 95% confidence interval [CI], 0.36 to 0.76) and definite nonfatal myocardial infarctions (relative risk, 0.49; 95% CI, 0.28 to 0.85), when compared with those who consumed nuts less than once per week. These findings persisted on covariate adjustment and were seen in almost all of 16 different subgroups of the population. Subjects who usually consumed whole wheat bread also experienced lower rates of definite nonfatal myocardial infarction (relative risk, 0.56; 95% CI, 0.35 to 0.89) and definite fatal CHD (relative risk, 0.89; 95% CI, 0.60 to 1.33) when compared with those who usually ate white bread. Men who ate beef at least three times each week had a higher risk of definite fatal CHD (relative risk, 2.31; 95% CI, 1.11 to 4.78), but this effect was not seen in women or for the nonfatal myocardial infarction end point.

Conclusion:  Our data strongly suggest that the frequent consumption of nuts may protect against risk of CHD events. The favorable fatty acid profile of many nuts is one possible explanation for such an effect.(Arch Intern Med. 1992;152:1416-1424)
Keyword Cholesterol-free diets
Experimental atherosclerosis
Fish consumption
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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