Chlamydia pneumoniae infection after lung transplantation

Glanville, Allan R., Gencay, Mesut, Tamm, Michael, Chhajed, Prashant, Plit, Marshall, Hopkins, Peter, Aboyoun, Christina, Roth, Michael and Malouf, Monique (2005) Chlamydia pneumoniae infection after lung transplantation. Journal of Heart and Lung Transplantation, 24 2: 131-136. doi:10.1016/j.healun.2003.09.042

Author Glanville, Allan R.
Gencay, Mesut
Tamm, Michael
Chhajed, Prashant
Plit, Marshall
Hopkins, Peter
Aboyoun, Christina
Roth, Michael
Malouf, Monique
Title Chlamydia pneumoniae infection after lung transplantation
Formatted title
Chlamydia pneumoniae infection after lung transplantation
Journal name Journal of Heart and Lung Transplantation   Check publisher's open access policy
ISSN 1053-2498
Publication date 2005-02
Sub-type Article (original research)
DOI 10.1016/j.healun.2003.09.042
Volume 24
Issue 2
Start page 131
End page 136
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
Background: Chlamydia pneumoniae is established as a common agent of acute respiratory tract infection and has been implicated in the pathogenesis of asthma and chronic obstructive pulmonary disease. Airway disease is a prominent cause of morbidity and mortality after lung transplantation. We investigated the role of C pneumoniae as a pulmonary pathogen after lung transplantation.
Methods: Eighty lung transplant recipients underwent 232 bronchoscopies with bronchoalveolar lavage with or without transbronchial lung biopsy during 1 year for surveillance of rejection and infection, or where clinically indicated.
Results: C pneumoniae was detected using nested polymerase chain reaction in 9 of 36 (25%) recipients studied within 30 days of lung transplantation, 3 of whom remained positive on repeat lavage and died from airway disease in the first year post-operatively. By comparison, all 27 recipients with negative lavage survived >1 year. Lavage was positive for C pneumoniae in 18 of 71 (25%) recipients studied >30 days after lung transplantation, 5 of whom had pneumonia and 8 of whom had bronchiolitis obliterans syndrome. Eleven also had acute pulmonary allograft rejection.
Conclusions: Persistent infection with C pneumoniae (whether donor-derived, de novo or re-activated) appears deleterious to pulmonary allograft function and is associated with early mortality, rejection and bronchiolitis obliterans syndrome after lung transplantation. A trial of empiric antibiotic therapy for C pneumoniae may therefore be warranted in the attempt to prevent progressive inflammatory airway disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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