Influence of internal fixator stiffness on murine fracture healing as characterized by mechanical testing and microCT imaging

Steck, Roland, Ueno, Masaki, Gregory, Laura, Rijken, Noortje, Wullschleger, Martin E., Itoman, Moritoshi and Schuetz, Michael A. (2011) Influence of internal fixator stiffness on murine fracture healing as characterized by mechanical testing and microCT imaging. Journal of Orthopaedic Research, 29 8: 1245-1250. doi:10.1002/jor.21341


Author Steck, Roland
Ueno, Masaki
Gregory, Laura
Rijken, Noortje
Wullschleger, Martin E.
Itoman, Moritoshi
Schuetz, Michael A.
Title Influence of internal fixator stiffness on murine fracture healing as characterized by mechanical testing and microCT imaging
Journal name Journal of Orthopaedic Research   Check publisher's open access policy
ISSN 0736-0266
1554-527X
Publication date 2011-01-15
Sub-type Article (original research)
DOI 10.1002/jor.21341
Volume 29
Issue 8
Start page 1245
End page 1250
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2012
Language eng
Abstract Mechanically well-defined stabilization systems have only recently become available, providing standardized conditions for studying the role of the mechanical environment on mouse bone fracture healing. The aim of this study was to characterize the time course of strength recovery and callus development of mouse femoral osteotomies stabilized with either low or high flexibility (in bending and torsion) internal fixation plates. Animals were euthanized and femora excised at 14, 21, and 28 days post-osteotomy for microCT analysis and torsional strength testing. While a larger mineralized callus was observed in osteotomies under more flexible conditions at all time points, the earlier bridging of the mineralized callus under less flexible conditions by 1 week resulted in an earlier recovery of torsional strength in mice stabilized with low flexibility fixation. Ultimate torque values for these bones were significantly higher at 14 and 21 days post-osteotomy compared to bones with the more flexible stabilization. Our study confirms the high reproducibility of the results that are achieved with this new implant system, therefore making it ideal for studying the influence of the mechanical environment on murine fracture healing under highly standardized conditions. (C) 2011 Orthopaedic Research Society.
Keyword Murine fracture model
Fracture healing
Torsional strength
Internal fixation
Locking plates
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 01 Nov 2011, 18:32:20 EST by Martin Wullschleger on behalf of Surgery - Royal Brisbane and Women's Hospital