The challenge of establishing preclinical models for segmental bone defect research

Reichert, Johannes C., Saifzadeh, Siamak, Wullschleger, Martin E., Epari, Devakara R., Schutz, Michael A., Duda, Georg N., Schell, Hanna, van Griensven, Martijn, Redl, Heinz and Hutmacher, Dietmar W. (2009) The challenge of establishing preclinical models for segmental bone defect research. Biomaterials, 30 12: 2149-2163. doi:10.1016/j.biomaterials.2008.12.050

Author Reichert, Johannes C.
Saifzadeh, Siamak
Wullschleger, Martin E.
Epari, Devakara R.
Schutz, Michael A.
Duda, Georg N.
Schell, Hanna
van Griensven, Martijn
Redl, Heinz
Hutmacher, Dietmar W.
Title The challenge of establishing preclinical models for segmental bone defect research
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
Publication date 2009-04
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2008.12.050
Volume 30
Issue 12
Start page 2149
End page 2163
Total pages 15
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Abstract A considerable number of international research groups as well as commercial entities work on the development of new bone grafting materials, carriers, growth factors and specifically tissue-engineered constructs for bone regeneration. They are strongly interested in evaluating their concepts in highly reproducible large segmental defects in preclinical and large animal models. To allow comparison between different studies and their outcomes, it is essential that animal models, fixation devices, surgical procedures and methods of taking measurements are well standardized to produce reliable data pools and act as a base for further directions to orthopaedic and tissue engineering developments, specifically translation into the clinic. In this leading opinion paper, we aim to review and critically discuss the different large animal bone defect models reported in the literature. We conclude that most publications provide only rudimentary information on how to establish relevant preclinical segmental bone defects in large animals. Hence, we express our opinion on methodologies to establish preclinical critically sized, segmental bone defect models used in past research with reference to surgical techniques, fixation methods and postoperative management focusing on tibial fracture and segmental defect models.
Keyword Bone defects
Bone engineering
Animal models
Preclinical studies
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 01 Nov 2011, 17:56:27 EST by Martin Wullschleger on behalf of Surgery - Royal Brisbane and Women's Hospital