Genetic determinants of diabetes are similarly associated with other immune-mediated diseases

Duffy, David L. (2007) Genetic determinants of diabetes are similarly associated with other immune-mediated diseases. Current Opinion in Allergy and Clinical Immunology, 7 6: 468-474. doi:10.1097/ACI.0b013e3282f1dc99


Author Duffy, David L.
Title Genetic determinants of diabetes are similarly associated with other immune-mediated diseases
Journal name Current Opinion in Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 1528-4050
1473-6322
Publication date 2007-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/ACI.0b013e3282f1dc99
Volume 7
Issue 6
Start page 468
End page 474
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
PURPOSE OF REVIEW:
I discuss the increasing number of genes discovered to exert pleiotropic action on susceptibility to diabetes and simultaneously to other immune-mediated diseases. While a genetic correlation between type 1 diabetes and autoimmunity is not surprising, the mechanism of a relationship to other conditions such as atopy is less obvious. The recent wave of genome-wide association studies offers confirmation of previously recognized risk loci, but also novel loci that also are likely to act via multiple pathogenetic pathways. I will review this material more in a genetical than an immunological way.

RECENT FINDINGS
:
Identification of IFIH1, an RNA helicase involved in the innate immune response to viral infection as a risk factor for type 1 diabetes and rheumatoid arthritis. Confirmation of the roles of CTLA4 and PTPN22 as general immune function modulators with a nonlinear dose-response effect on autoimmunity, and confirmation of the role of IL2RA, which may act via a regulatory T cell subset on immune disease risk. Expansion of the role of PPARG in immunity.

SUMMARY
:
The wave of genome-wide association studies already experienced in the last 2 years has solidified what we thought we knew and added a list of genes in new pathways. The association of IFIH1 with type 1 diabetes may offer a real window into early events in the development of that disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: ERA 2012 Admin Only
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 01 Nov 2011, 10:30:11 EST by Matthew Lamb on behalf of School of Medicine