Fluorous synthesis of minor groove binding agents related to distamycin

Mamidyala, Sreeman K. and Firestine, Steven M. (2006) Fluorous synthesis of minor groove binding agents related to distamycin. Tetrahedron Letters, 47 42: 7431-7434. doi:10.1016/j.tetlet.2006.08.058


Author Mamidyala, Sreeman K.
Firestine, Steven M.
Title Fluorous synthesis of minor groove binding agents related to distamycin
Journal name Tetrahedron Letters   Check publisher's open access policy
ISSN 0040-4039
1873-3581
Publication date 2006-09-11
Sub-type Article (original research)
DOI 10.1016/j.tetlet.2006.08.058
Volume 47
Issue 42
Start page 7431
End page 7434
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Formatted abstract
Minor groove binding agents related to distamycin have been shown to target specific DNA sequences with high affinity. We report a new method for the preparation of these agents using fluorous synthesis in which the fluorous tag is located on what will become the cationic tail of the molecule. We demonstrate that fluorous synthesis yields both simple and complex polyamides in good yields and in high purity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Sun, 30 Oct 2011, 11:03:35 EST by Sreeman Mamidyala on behalf of Institute for Molecular Bioscience