Natural history of idiopathic diabetes insipidus

Richards, Gail E., Thomsett, Michael J., Boston, Bruce A., DiMeglio, Linda A., Shulman, Dorothy I. and Draznin, Martin (2011) Natural history of idiopathic diabetes insipidus. Journal of Pediatrics, 159 4: 566-570. doi:10.1016/j.jpeds.2011.03.044

Author Richards, Gail E.
Thomsett, Michael J.
Boston, Bruce A.
DiMeglio, Linda A.
Shulman, Dorothy I.
Draznin, Martin
Title Natural history of idiopathic diabetes insipidus
Journal name Journal of Pediatrics   Check publisher's open access policy
ISSN 0022-3476
Publication date 2011-10
Sub-type Article (original research)
DOI 10.1016/j.jpeds.2011.03.044
Volume 159
Issue 4
Start page 566
End page 570
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Mosby
Collection year 2012
Language eng
Formatted abstract
Objective To determine what percentage of diabetes insipidus (DI) in childhood is idiopathic and to assess the natural history of idiopathic DI.

Study design
We conducted a retrospective chart review of 105 patients with DI who were born or had DI diagnosed between 1980-1989 at 3 medical centers. A second cohort of 30 patients from 6 medical centers in whom idiopathic DI was diagnosed after 1990 was evaluated retrospectively for subsequent etiologic diagnoses and additional hypothalamic/pituitary deficiencies and prospectively for quality of life.

In the first cohort, 11% of patients had idiopathic DI. In the second cohort, additional hypothalamic/pituitary hormone deficiencies developed in 33%, and 37% received an etiologic diagnosis for DI. Health-related quality of life for all the patients with idiopathic DI was comparable with the healthy reference population.

Conclusions Only a small percentage of patients with DI will remain idiopathic after first examination. Other hormone deficiencies will develop later in one-third of those patients, and slightly more than one-third of those patients will have an etiology for the DI diagnosed. Long-term surveillance is important because tumors have been diagnosed as long as 21 years after the onset of DI. Quality of life for these patients is as good as the reference population.
Keyword Pituitary-Stalk
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
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