Immunobiology of Human Cytomegalovirus: from Bench to Bedside

Crough, Tania and Khanna, Rajiv (2009) Immunobiology of Human Cytomegalovirus: from Bench to Bedside. Clinical Microbiology Reviews, 22 1: 76-98. doi:10.1128/CMR.00034-08

Author Crough, Tania
Khanna, Rajiv
Title Immunobiology of Human Cytomegalovirus: from Bench to Bedside
Journal name Clinical Microbiology Reviews   Check publisher's open access policy
ISSN 0893-8512
Publication date 2009-01
Sub-type Article (original research)
DOI 10.1128/CMR.00034-08
Volume 22
Issue 1
Start page 76
End page 98
Total pages 23
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency and periodically reactivates without causing symptoms in healthy individuals. In the absence of an adequate host-derived immune response, this fine balance of permitting viral reactivation without causing pathogenesis is disrupted, and HCMV can subsequently cause invasive disease and an array of damaging indirect immunological effects. Over the last decade, our knowledge of the immune response to HCMV infection in healthy virus carriers and diseased individuals has allowed us to translate these findings to develop better diagnostic tools and therapeutic strategies. The application of these emerging technologies in the clinical setting is likely to provide opportunities for better management of patients with HCMV-associated diseases.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 220 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 27 Oct 2011, 13:45:27 EST by Geraldine Fitzgerald on behalf of School of Public Health