Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma

de Koning, Maurits N.C., Weissenborn, Sonke J., Abeni, Damiano, Bavinck, Jan Nico Bouwes, Euvrard, Sylvie, Green, Adele C., Harwood, Catherine A., Naldi, Luigi, Neale, Rachel, Nindl, Ingo, Proby, Charlotte M., Quint, Wim G. V., Sampogna, Francesca, ter Schegget, Jan, Struijk, Linda, Wieland, Ulrike, Pfister, Herbert J., Feltkamp, Mariet C. W. and EPI-HPV-UV-CA group (2009) Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma. Journal of General Virology, 90 7: 1611-1621. doi:10.1099/vir.0.010017-0

Author de Koning, Maurits N.C.
Weissenborn, Sonke J.
Abeni, Damiano
Bavinck, Jan Nico Bouwes
Euvrard, Sylvie
Green, Adele C.
Harwood, Catherine A.
Naldi, Luigi
Neale, Rachel
Nindl, Ingo
Proby, Charlotte M.
Quint, Wim G. V.
Sampogna, Francesca
ter Schegget, Jan
Struijk, Linda
Wieland, Ulrike
Pfister, Herbert J.
Feltkamp, Mariet C. W.
Title Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 0022-1317
Publication date 2009
Sub-type Article (original research)
DOI 10.1099/vir.0.010017-0
Volume 90
Issue 7
Start page 1611
End page 1621
Total pages 11
Place of publication Berks, United Kingdom
Publisher Society for General Microbiology
Language eng
Formatted abstract
Betapapillomavirus (betaPV) infections are often associated with squamous-cell carcinoma (SCC) and the prevalence of betaPV infections in (immunosuppressed) SCC patients is known to be high. The distribution and possible associated factors of betaPV infections in the general population, however, are largely unknown. To address this issue, betaPV infection was studied in 1405 SCC-free immunocompetent (n=845) and immunosuppressed (n=560) individuals from six countries of different latitudes. A standard study protocol was used to obtain information about age, sex, UV-irradiation and skin type, and from all participants eyebrow hairs were collected for detection and genotyping of 25 established betaPV types using the PM-PCR reverse hybridization assay (RHA) method. The frequency of betaPV-positive participants ranged from 84 to 91 % in the immunocompetent population with HPV23 as the most prevalent type, and from 81 to 98 % in the immunosuppressed population with HPV23 as the most or the second most prevalent type. The median number of infecting betaPV types ranged from four to six in the immunocompetent and from three to six in the immunosuppressed population. Increasing age in the immunocompetent participants and (duration of) immunosuppression in the immunosuppressed patients were associated with betaPV infection. In both groups, sex, skin phototype, sunburns and sun-exposure were not consistently associated with betaPV infection. This study demonstrates that betaPV infections are also highly prevalent in SCC-free individuals, with similar HPV types prevailing in both immunocompetent and immunosuppressed persons. Age and (duration of) immunosuppression were identified as betaPV infection-associated factors, whereas characteristics related to sun exposure and skin type were not.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 25 Oct 2011, 15:54:43 EST by Geraldine Fitzgerald on behalf of School of Public Health