Malaria vaccine design: Immunological Considerations

Good, Michael F. and Doolan, Denise L. (2010) Malaria vaccine design: Immunological Considerations. Immunity, 33 4: 555-566. doi:10.1016/j.immuni.2010.10.005

Author Good, Michael F.
Doolan, Denise L.
Title Malaria vaccine design: Immunological Considerations
Journal name Immunity   Check publisher's open access policy
ISSN 1074-7613
Publication date 2010-10
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.immuni.2010.10.005
Volume 33
Issue 4
Start page 555
End page 566
Total pages 12
Place of publication Cambridge, MA, United States
Publisher Cell Press
Language eng
Formatted abstract
The concept of a malaria vaccine has sparked great interest for decades; however, the challenge is proving to be a difficult one. Immune dysregulation by Plasmodium and the ability of the parasite to mutate critical epitopes in surface antigens have proved to be strong defense weapons. This has led to reconsideration of polyvalent and whole parasite strategies and ways to enhance cellular immunity to malaria that may be more likely to target conserved antigens and an expanded repertoire of antigens. These and other concepts will be discussed in this review.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: ERA 2012 Admin Only
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 59 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 25 Oct 2011, 14:26:37 EST by Geraldine Fitzgerald on behalf of School of Public Health