Endocrine pancreatic function in growth-retarded fetuses

Hubinont, C., Nicolini, U., Fisk, N.M., Tannirandorn, Y. and Rodeck, C.H. (1991) Endocrine pancreatic function in growth-retarded fetuses. Obstetrics and Gynecology, 77 4: 541-544.

Author Hubinont, C.
Nicolini, U.
Fisk, N.M.
Tannirandorn, Y.
Rodeck, C.H.
Title Endocrine pancreatic function in growth-retarded fetuses
Journal name Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0029-7844
1873-233X
Publication date 1991-04
Sub-type Article (original research)
Volume 77
Issue 4
Start page 541
End page 544
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract Maternal-fetal glucose gradient and fetal plasma glucose, insulin, and glucagon were measured in 63 fetuses: 34 controls and 29 with growth retardation (nine with and 20 without end-diastolic frequencies in the umbilical artery). Maternal-fetal glucose gradient and fetal glucagon levels were higher in the growth-retarded group than in controls (P < .001), whereas fetal insulin and glucose concentrations were lower (P < .001). Although maternal-fetal glucose gradient, fetal glucose, and insulin concentrations were similar among the growth-retarded fetuses, fetuses without end-diastolic frequencies in the umbilical artery had higher fetal glucagon levels (P = .01) than those with end-diastolic frequencies. In growth-retarded fetuses, the increase in fetal glucagon might reflect a compensatory response to hypoglycemia and appears to be a better index of fetal compromise than is glucose or insulin.
Keyword For-gestational-age
Glucose-homeostasis
Fetal
Metabolism
Infant
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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