High failure rate of postmortem karyotyping after termination for fetal abnormality

Kyle, Phillipa M., Sepulveda, Waldo, Blunt, Susan, Davies, Graham, Cox, Phillip M. and Fisk, Nicholas M. (1996) High failure rate of postmortem karyotyping after termination for fetal abnormality. Obstetrics and Gynecology, 88 5: 859-862. doi:10.1016/0029-7844(96)00311-0


Author Kyle, Phillipa M.
Sepulveda, Waldo
Blunt, Susan
Davies, Graham
Cox, Phillip M.
Fisk, Nicholas M.
Title High failure rate of postmortem karyotyping after termination for fetal abnormality
Journal name Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0029-7844
1873-233X
Publication date 1996-11
Sub-type Article (original research)
DOI 10.1016/0029-7844(96)00311-0
Volume 88
Issue 5
Start page 859
End page 862
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Objective:
To determine the failure rate of karyotyping from samples taken after termination of pregnancy for fetal abnormality.

Methods:
Perinatal autopsy reports over a 12-month period were reviewed to identify those with cytogenetic studies performed after termination of pregnancy for fetal abnormality.

Results:
During the audit period, there were 104 terminations for fetal abnormality. In 89 fetuses, fetal skin (n = 85), placenta (n = 62), or other samples (n = 8) were obtained for postmortem cytogenetic analysis. In 24 (27%) fetuses, postmortem tissues did not yield a karyotype result. The failure rate of post-termination karyotyping was significantly influenced by delivery-sampling interval, but not by gestational age, type of tissue sampled, use of potassium chloride, or aneuploidy. Of the 24 cases for which no post-termination karyotype was obtained, 16 had had successful pre-termination karyotyping, resulting in only eight of 89 (9%) cases in the overall series not having a final karyotype.

Conclusion:
The high failure rate for post-termination karyotyping suggests that a pre-termination procedure is necessary if parents wish to have almost 100% certainty that cytogenetic information will be available for later genetic counseling.
Keyword Perinatal-mortality
Stillbirths
Death
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 24 Oct 2011, 17:31:56 EST by System User on behalf of Faculty Of Health Sciences