Molecular genetic etiology of twin reversed arterial perfusion sequence

Fisk, Nicholas M., Ware, Mark, Stanier, Philip, Moore, Gudrun and Bennett, Phillip (1996) Molecular genetic etiology of twin reversed arterial perfusion sequence. American Journal of Obstetrics and Gynecology, 174 3: 891-894. doi:10.1016/S0002-9378(96)70320-4


Author Fisk, Nicholas M.
Ware, Mark
Stanier, Philip
Moore, Gudrun
Bennett, Phillip
Title Molecular genetic etiology of twin reversed arterial perfusion sequence
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
1097-6868
Publication date 1996-03-01
Sub-type Article (original research)
DOI 10.1016/S0002-9378(96)70320-4
Volume 174
Issue 3
Start page 891
End page 894
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
OBJECTIVE:
Our purpose was to determine whether the twin reversed arterial perfusion sequence (acardiac anomaly) results from fertilization of the first or second polar body.

STUDY DESIGN:

Placental or fetal tissue was obtained from nine twin sets discordant for twin reversed arterial perfusion. After deoxyribonucleic acid extraction, the polymerase chain reaction was used to amplify five polymorphic microsatellite repeats. The products were differentiated by polyacrylamide gel electrophoresis, and patterns were compared within twin sets.

RESULTS:
Deoxyribonucleic acid fingerprinting patterns were identical in all twin sets for all primer pairs. It is calculated that the chance that any of the acardiac twins resulted from fertilization of either the first or second polar body is <4% and the chance that they all resulted from polar body fertilization is <0.001%.

CONCLUSIONS:
Twins discordant for the twin reversed arterial perfusion sequence anomaly are monozygous. Our results exclude polar body fertilization as a likely cause of this condition.
Keyword Twin reversed arterial perfusion
Acardiac twin
Zygosity deoxyribonucleic acid fingerprinting
Polar body fertilization
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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