Acute Severe Colitis: Infliximab and/or Cyclosporine?

Fabro, Mauro, Szabo, Hajnalka, Terrosu, Giovanni, Avellini, Claudio, Tabuso, Maria, Fiorino, Gionata and Sorrentino, Dario (2011) Acute Severe Colitis: Infliximab and/or Cyclosporine?. Current Drug Targets, 12 10: 1448-1453.


Author Fabro, Mauro
Szabo, Hajnalka
Terrosu, Giovanni
Avellini, Claudio
Tabuso, Maria
Fiorino, Gionata
Sorrentino, Dario
Title Acute Severe Colitis: Infliximab and/or Cyclosporine?
Journal name Current Drug Targets   Check publisher's open access policy
ISSN 1389-4501
1873-5592
Publication date 2011-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/138945011796818234
Volume 12
Issue 10
Start page 1448
End page 1453
Total pages 6
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2012
Language eng
Formatted abstract Acute severe ulcerative colitis is a serious condition that requires early hospitalization, with intensive monitoring and treatment. Despite the recent progress in the medical approach of Inflammatory Bowel Diseases acute severe ulcerative colitis remains a clinical challenge, with a mortality rate of nearly 1%.

As of today, I.V. corticosteroids remain the 1st-line therapy for this complication. For non-responders (up to one-third of patients) possible options are surgery - whose timing is a critical point in the overall management of the disease - or rescue therapy with 2nd- line agents such as Cyclosporine and Infliximab. Here we will review the published studies dealing with the use of these medications in acute severe ulcerative colitis.
Keyword Severe colitis
Corticosteroids
Cyclosporine
Infliximab
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Medicine Publications
 
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