Acute Severe Colitis: Infliximab and/or Cyclosporine?

Fabro, Mauro, Szabo, Hajnalka, Terrosu, Giovanni, Avellini, Claudio, Tabuso, Maria, Fiorino, Gionata and Sorrentino, Dario (2011) Acute Severe Colitis: Infliximab and/or Cyclosporine?. Current Drug Targets, 12 10: 1448-1453. doi:10.2174/138945011796818234

Author Fabro, Mauro
Szabo, Hajnalka
Terrosu, Giovanni
Avellini, Claudio
Tabuso, Maria
Fiorino, Gionata
Sorrentino, Dario
Title Acute Severe Colitis: Infliximab and/or Cyclosporine?
Journal name Current Drug Targets   Check publisher's open access policy
ISSN 1389-4501
Publication date 2011-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/138945011796818234
Volume 12
Issue 10
Start page 1448
End page 1453
Total pages 6
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2012
Language eng
Formatted abstract
Acute severe ulcerative colitis is a serious condition that requires early hospitalization, with intensive monitoring and treatment. Despite the recent progress in the medical approach of Inflammatory Bowel Diseases acute severe ulcerative colitis remains a clinical challenge, with a mortality rate of nearly 1%.

As of today, I.V. corticosteroids remain the 1st-line therapy for this complication. For non-responders (up to one-third of patients) possible options are surgery - whose timing is a critical point in the overall management of the disease - or rescue therapy with 2nd- line agents such as Cyclosporine and Infliximab. Here we will review the published studies dealing with the use of these medications in acute severe ulcerative colitis.
Keyword Severe colitis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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