Regional assessment of ambient volatile organic compounds from biopharmaceutical R&D complex

Pan, Y., Liu, Q., Liu, F. F., Qian, G. R. and Xu, Z. P. (2011) Regional assessment of ambient volatile organic compounds from biopharmaceutical R&D complex. Science of the Total Environment, 409 20: 4289-4296. doi:10.1016/j.scitotenv.2011.07.014

Author Pan, Y.
Liu, Q.
Liu, F. F.
Qian, G. R.
Xu, Z. P.
Title Regional assessment of ambient volatile organic compounds from biopharmaceutical R&D complex
Journal name Science of the Total Environment   Check publisher's open access policy
ISSN 0048-9697
Publication date 2011-09-15
Sub-type Article (original research)
DOI 10.1016/j.scitotenv.2011.07.014
Volume 409
Issue 20
Start page 4289
End page 4296
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2012
Language eng
Abstract Biopharmaceutical R&D complexes are major emission sources of volatile organic compounds (VOCs), which may pose potential health risks for staff on site and residents nearby. In this paper health risk assessments were performed for the VOCs in the ambient air of a typical biopharmaceutical R&D complex in China. Results showed halogenated and alkyl compounds were dominant components among 24 major VOCs from 9 selected sampling sites, inside or around the complex. The principal component analysis (PCA) indicated VOCs were generated predominantly from the biopharmaceutical research activities (factor 1 (F1), 71.6%) and traffic vehicles (factor 2 (F2), 15.4%), which were confirmed by contour maps of five selected VOCs (benzene, toluene, chlorobenzene, methylene chloride and n-hexane) simulated by Golden Software Surfer. The cumulative cancer risks for the staff on site and residents nearby were investigated and results showed the risk value were 1.01E−5 and 2.03E−5, respectively, higher than the threshold value of 1.0E−6. These results indicated that elevated VOCs from biopharmaceutical R&D complex are potential risks to the public health. Furthermore, the human health risk assessment revealed that 1,2-dichloroethane, methylene chloride, carbon tetrachloride and benzene were the dominant risk contributors for staff on site, while methyl chloride, carbon tetrachloride, 1,2-dichloroethane and tetrahydrofuran for residents nearby. As a conclusion, this work suggests that proper control strategy should be taken for VOCs releasing to minimize the public health risks, especially for the halogenated compounds.
Keyword Biopharmaceutical R&D complex
Volatile organic compounds (VOCs)
Emission source discrimination
Human health risk assessment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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